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    Title Scientific Insights into Clostridium butyricum S-45-5 and Short-Chain Fatty Acids for Gut and Metabolic Health
    Date 2026.08.25 (16:20 - 16:50) | Hall C Seminar room
    Organization NPK Inc.
    Speaker Han Seong-jeong, Principal Researcher/Ph.D
    Speaker & Lecture Information

    [Brief Introduction of Seminar]

    Scientific research on Clostridium butyricum S-45-5 and its major metabolites, short-chain fatty acids (SCFAs), has highlighted their potential as functional ingredients for gut health and metabolic health.

     Clostridium butyricum S-45-5 may contribute to the maintenance of a healthy intestinal environment through gut microbiota modulation and the production of beneficial metabolites. Among these metabolites, SCFAs play key roles in maintaining the intestinal environment, strengthening the gut barrier, and regulating inflammatory responses. In addition to their well-known relevance to gut health, Clostridium butyricum S-45-5 and SCFAs are increasingly recognized as important targets in metabolic health research, including blood glucose regulation, improvement of insulin resistance, and modulation of obesity and body fat accumulation.

     Based on this scientific background, SCFA 455, a functional ingredient derived from Clostridium butyricum S-45-5 and its metabolites, is being developed as a potential functional material for gut health and metabolic health. Preclinical research findings on SCFA 455 provide scientific evidence supporting the application of Clostridium butyricum- and metabolite-based materials in the development of food and health functional food ingredients.

     

    [Brief Introduction of Speaker]

    The research is based on expertise in molecular endocrinology, biochemistry, and microbiology, with a focus on optimizing microbial cultivation processes and investigating the functional properties of microbiome-derived ingredients through the Gut-Organ Axis. This includes functional evaluation studies related to various physiological activities, including gut health and metabolic health.

    Academic Background: Bachelor’s, Master’s, and Doctoral programs at Chonnam National University, conducting research on the redox regulation of PTEN and selenoproteins. This was followed by international collaborative research experience with Brigham and Women’s Hospital, an affiliate of Harvard Medical School. Current research focuses on Clostridium butyricum S-45-5 and its metabolites, particularly short-chain fatty acids (SCFAs), as functional microbiome-derived ingredients.

    Industry Experience: Industry experience includes leading multiple industry-academia collaborative projects related to the development of natural product-based cosmetic ingredients, microbiome-derived functional ingredients, evaluation of efficacy in gut health and metabolic health, technology transfer, and the creation of intellectual property such as patents and publications. This experience covers an integrated R&D scope, from establishing scientific evidence for functional ingredients to developing regulatory approval strategies.​ 

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